PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 1, 1996

 Article

Immunohistochemical Expression of N-ras Oncogene is a Late Event in Head and Neck Carcinomas

John S MCDONALD1, Keith M WILSON1, Peter GARTSIDE2, Robert L SONKE1, Ljiljana PAVELIC1, Eric OKUM3, Julie NEANEN3, Jack L GLUCKMAN1, Zlatko P PAVELIC1

1Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, USA
2Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, USA
3Medical School, Ohio State University, Columbus, USA

 

This study investigated the expression of the N-ras oncogene in routinely processed tissue sections from 133 patients with squamous cell carcinoma of the head and neck (SCCHN) by immunohistochemistry using anti-N-ras monoclonal antibody. N-ras expression was present in 67 of 133 (49.6%) cases. There was a highly significant correlation between N-ras expression and clinical stage of disease (P=0.003). This study confirmed that overexpression of the N-ras oncogene is common in SCCHN and that it may be an important event in the late stage of disease. Pathology & Oncology Research, Vol 2, Nr 1, 30-33, 1996

Key words: head and neck cancer; immunohistochemistry; N-ras


Received: Mar 11, 1996; accepted: Apr 2, 1996
Correspondence: Zlatko P PAVELIC, Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati 45167-0528, USA; Tel: (513)5586275, Fax: (513)5585203

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