PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 1, 1996

 Article

nm23-H1 Expression in Squamous Cell Carcinoma of the Head and Neck

John S MCDONALD1, Peter S GARTSIDE2, Ljiljana J PAVELIC1, Jack L GLUCKMAN1, Zlatko P PAVELIC1

1Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, USA
2Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, USA

 

Archival material from 47 patients with primary squamous cell carcinoma of the head and neck (SCCHN) was studied immunohistochemically for the presence of nm23-H1 protein. Our data indicate that nm23-H1 protein expression is a common event in SCCHN and that there is a trend toward correlation of increased expression of nm23-H1 with increasing tumor size (p = 0.072). The results also show that when adjusting for age and cause of death, there tended to be an inverse relationship between overall survival and the expression of nm23-H1 gene in the primary tumor (p = 0.088). Pathology & Oncology Research, Vol 2, Nr 1, 34-36, 1996

Key words: head and neck cancer; nm23-H1 gene expression; immmunohistochemistry; prognosis


Received: Mar 14, 1996; accepted: Apr 12, 1996
Correspondence: Zlatko P PAVELIC, Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati 45267-0528, USA; Tel: (513)5586275, Fax: (513)5585203

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