PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 2, 1996

 Article

Marker Enzymes of Rat Chemical Hepatocarcinogenesis in Human Liver Tumors

Ilona KOVALSZKY, Zsuzsa SCHAFF, Károly LAPIS, András JENEY

1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary

 

Reduced glucose-6-phosphatase, increased GGT activity and reduction of cytochrome P-450 content are considered to be markers of chemical hepatocarcinogenesis in rats. The significance of these changes were studied in certain human liver lesions; adenoma, focal nodular hyperplasia and hepatocellular carcinoma all developed in non-cirrhotic livers. Enzymes showed normal values in 4 out of 5 adenomas, in 2/13 FNH and in 4/18 HCC samples. The decreased cP-450 content in HCC proved to be the most consistent alteration (12/18). Only 3 HCC samples possessed changes off all enzymes. These data suggest that at least those enzymes which are used as markers in rat chemical hepatocarcinogenesis have little or no biological significance in human liver tumors, primarily due to the intertumoral heterogeneity of enzyme activity. Such heterogeneity was observed in the peritumoral ''normal'' liver tissue, too. Pathology & Oncology Research, Vol 2, Nr 2, 56-58, 1996

Key words: liver tumor; GGT; G-6-Pase; cytochrome P-450


Received: Dec 20, 1995; accepted: Feb 6, 1996
Correspondence: Ilona KOVALSZKY, 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllõi út 26. Budapest H-1085, Hungary; Tel: 36-1-1331142, Fax: 36-1-1331142; E-mail: koval@korb1.sote.hu

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