PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 2, 1996

 Article

The Effect Of Long Term and High Dose Interferon Treatment In Chronic Hepatitis C

Gábor HORVÁTH1, Gyula STOTZ2, Gyula TOLVAJ1, Henrik OSZTROGONÁCZ1, Károly DÁVID1

11st Department of Medicine, Central Hospital of the Ministry of the Interior, Budapest, Hungary
2Department of Pathology, Central Hospital of the Ministry of the Interior, Budapest, Hungary

 

The results of 43 interferon treatments of 35 patients (23 male, 12 female) are reported. The duration of the treatment was 6-18 months, the dose of interferon was 3x3-5 MU weekly. Complete response (HCV RNA became negative) was found in 11, relapse was observed in 3 patients. Partial response (transaminase levels became normal, or less than twice normal value, but patients remained HCV RNA positive) occurred in 23 cases, relapse was obeserved in 16. The therapy had no effect in 9 cases. The higher dose and longer term interferon therapy resulted in a higher rate of response to the treatment and a reduction in the number of relapses. Pathology & Oncology Research, Vol 2, Nr 2, 59-62, 1996

Key words: chronic hepatitis C; interferon treatment


Received: Feb 12, 1996; accepted: Mar 3, 1996
Correspondence: Gábor HORVÁTH, 1st Department of Medicine, Central Hospital of the Ministry of the Interior, Budakeszi út 48/b Budapest 1121, Hungary; Tel: 36-1-1560522, Fax: 36-1-1761840

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