PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 2, 1996

 Article

Total IgA and IgG in Sera of Patients With Different Primary Malignancies

Terezija M HRZENJAK1, Ante ROGULJIC2, Palma EFENBERGER-MARINCULIC3, Maja POPOVIC1, Zoran PISL3

1Department of Biology, Faculty of Veterinary Medicine, Zagreb, Croatia
2Clinic for Tumors and Allied Diseases, Zagreb, Croatia
3Institute for Medical Research and Occupational Health, Zagreb, Croatia

 

The concentrations of total serum IgA and IgG of 267 patients with different primary malignant tumors were measured by ELISA. Total serum IgA increased by 30% to 40% in patients with malignancies associated with mucous membranes (nasopharyngeal, gastrointestinal and bronchial carcinomas), while the change in total serum IgG was negligible. Although, the changes in Ig level could be influenced by many host factors, these data call attention to the potential indicative role of total serum IgA levels. Further studies are required to establish links between serum IgA levels and stages of tumor growth or tumor progression in order to use these values as prognostic factors. Pathology & Oncology Research, Vol 2, Nr 2, 66-68, 1996

Key words: IgA; IgG; malignant tumors


Received: Jan 19, 1996; accepted: Feb 29, 1996
Correspondence: Terezija M HRZENJAK, Department of Biology, Faculty of Veterinary Medicine, Heinzelova 55. Zagreb 10000, Croatia; Tel: 01-2390142

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