PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 2, 1996

 Article

Experimental Study on the Carcinogenicity of the Cytostatic Drug Ftorafur (Tegafur)

Laima GRICIUTÉ, Vida DOMKIENÉ

Lithuanian Oncological Center, Vilnius, Lithuania

 

Long-term carcinogenicity of Ftorafur (Tegafur) was studied in rodents. Rats and mice were treated for one year per os with 40 (mice) and 60 (rat) mg/kg Ftorafur twice a week and were followed for their entire life. Analysis of the data provide no evidence for the carcinogenicity of Ftorafur in rodents. These findings are similar to other antimetabolite studies and contrasts with the carcinogenic alkylating agents. Pathology & Oncology Research, Vol 2, Nr 2, 69-70, 1996

Key words: Ftorafur; Tegafur; carcinogenicity; mouse; rat


Received: Dec 10, 1995; accepted: Mar 5, 1996
Correspondence: Laima GRICIUTÉ, Lithuanian Oncological Center, , Santariskíy 1. Vilnius 2600, Lithuania, Fax: 720164; E-mail: onko.centras@loc.lt

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