PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 2, 1996

 Report

Osteoclastoma-like Giant Cell Tumor of the Lung

Zsolt OROSZ1, Erika TÓTH2, Anna VISKI3

1Department of Human and Experimental Tumor Pathology, National Institute of Oncology, Budapest, Hungary
2Department of Molecular Pathology, National Institute of Oncology, Budapest, Hungary
3Department of Pathology, Kaposi Mór Hospital, Kaposvár, Hungary

 

The main components of an unusual form of lung tumor were osteoclast-like multinucleated giant cells and mononuclear stromal cells. Besides, scattered islands of moderately differentiated squamous cells also appeared. Both the mononuclear and the osteoclast-like giant cells reacted with antibodies against CD68 and vimentin, but did not react with antibodies against cytokeratin, EMA and CEA, or lysozyme and a-1-antitrypsin. The p53 and PCNA antigens were positive only in mononuclear cells and not the osteoclast-like giant cells, suggesting that mononuclear cells represent proliferating elements with histiocytic differentiation while osteoclast-like giant cells are stromal, presumably reactive components of the tumor. Pathology & Oncology Research, Vol 2, Nr 2, 84-88, 1996

Key words: osteoclast-like giant cells; giant cell tumor; lung; p53; PCNA


Received: Feb 3, 1996; accepted: Mar 10, 1996
Correspondence: Zsolt OROSZ, Department of Human and Experimental Tumor Pathology, National Institute of Oncology, Ráth György u. 7-9. Budapest 1122, Hungary

Click here to get the full-text version in PDF!
ad