p53 Immunohistochemical Expression of Egyptian Cervical Carcinoma

Howayda ABD EL ALL1, Annie RYE2, Pierre DUVILLARD3

1Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department of Statistics, Institute Gustave Roussy, Villejuif, France
3Department of Pathology, Institute Gustave Roussy, Villejuif, France


Data concerning the expression of p53 in cervical carcinoma, one of the leading cause of death in developing countries, are still confusing. This study was designed to identify p53 in Egyptian cervical carcinoma in an attempt to evaluate its prognostic significance. Eleven chronic cervicitis and 38 invasive carcinoma (31 squamous cell carcinoma (sqcc) and 7 adenocarcinoma, ranging from stage IB to IVB), were stained with the monoclonal antibody anti p53, DO7, using the microwave for antigen retrieval. No immunoreactivity was detected in chronic cervicitis, while nuclear p53 reactivity was detected in all carcinoma and in squamous intra-epithelial lesions (SIL) overlying 8 sqcc. P53 immunohistochemical (IHC) expression was more pronounced in early clinical stages (p=0.007) and in adenocarcinoma compared to sqcc (p=0.015). A positive correlation was present between p53 and heat shock protein 70 (hsp70) expressions (p=0.005). No correlation could be found between p53 expression and tumor infiltrating lymphocytes, the presence or absence of either schistosomiasis or HPV infections. It can be concluded, that in the Egyptian population, p53 immunoreactivity appears to be an early event in cervical neoplasm, and seems to play an important role together with other cell regulatory proteins in the process of carcinogenesis, which could be different between sqcc and adenocarcinoma. Pathology & Oncology Research, Vol 5, Nr 4, 280-284, 1999

Key words: cervical carcinoma; p53; FIGO staging

Received: May 2, 1998; accepted: Feb 10, 1999
Correspondence: Howayda ABD EL ALL, Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia , Egypt; Tel: + (202) 274-32-31, Fax: + (202) 274-36-70; E-mail:

Click here to get the full-text version in PDF!