Prostate Cancer, Old Problems and New Approaches Part I.

Epidemiology, Incidence and Genetic Alterations

Kenneth V HONN1, Amer AREF1, Yong Q CHEN2, Michael L CHER3, John D CRISSMAN2, Jeffrey D FORMAN1, Xiang GAO1, David GRIGNON2, Maha HUSSAIN4, Arthur T PORTER1, J Edson PONTES3, Isaac POWELL3, Bruce REDMAN4, Wael SAKR2, Richard SEVERSON5, Dean G TANG1, David P WOOD Jr.3

1Department of Radiation Oncology, Wayne State University, Detroit, USA
2Department of Pathology, Wayne State University, Detroit, USA
3Department of Urology, Wayne State University, Detroit, USA
4Department of Medicine, Wayne State University, Detroit, USA
5Department of Family Medicine, Wayne State University, Detroit, USA
6Barbara Ann Karmanos Cancer Institute, Detroit Medical Center, Detroit, USA


Rates of prostate cancer (PCa) have increased so dramatically over the last decade that the age adjusted incidence rate for PCa is now greater than that any other cancer among men in the United States. This review, published as a three part series, provides a state-of-art assessment of the PCa problem in its divergent aspects. Part 1 covers epidemiology, incidence and progression. Several epidemiological studies have demostrated that first degree male relatives of men with PCa are at increased risk of developing the disease. Familial and genetic factors as well as medical, anthropometric, dietary, hormonal and occupational factors involved in PCa are discussed. Postmortem examination of the prostate in men without evidence of PCa documented a high frequency of adenocarcinoma. Latent disease occurred as early as the second decade of life. Although there is no significant difference in incidence between Caucasian and African-American males, high grade prostatic intraepithelial neoplasia (HGPIN) is higher in the latter group. While dietary fat, androgens and certain environmental factors may be determinants for PCa, the exact mechanism of tumorigenesis is still relatively unknown. The current thinking of the role of genomic instability, chromosomal alterations, tumor suppressor genes and the androgen receptor are explored. Pathology & Oncology Research, Vol 2, Nr 2, 98-109, 1996

Key words: prostate cancer; epidemiology; incidence; genetics; progression

Received: Mar 2, 1996; accepted: Apr 1, 1996
Correspondence: Kenneth V HONN, Department of Radiation Oncology, Wayne State University, 431 Chemistry Detroit 48201, USA; Tel: 313-5771018, Fax: 313-5770798

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