PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 3, 1996

 Article

Intracerebral Human Lymphoma - An Experimental Model

Árpád TÓTTH, János SCHNUR, Andrea LADÁNYI, László KOPPER

1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary

 

Primary central nervous system lymphomas are rather rare, however, their frequency seems to be increasing in both high risk and immunocompetent patients with very poor prognosis. Here we describe a model intracerebrally xenotransplating human non Hodgkin lymphoma cells of B cell origin (HT 58). This offers a unique possibility to study the theraputic response, especially on systemic treatment. Briefly, one million lymphoma cells grew as meningeal tumor mass, infiltrating the brain directly as well as via the perivascular space. The lymphoma cells preserved all the phenotypic characteristics of the source tumor. Pathology & Oncology Research, Vol 2, Nr 3, 174-176, 1996

Key words: lymphoma; CNS; tumor-model


Received: Jul 11, 1996; accepted: Aug 10, 1996
Correspondence: László KOPPER, 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllõi út 26. Budapest H-1085, Hungary; Tel: 36-1-1170891; E-mail: kopper@korb1.sote.hu

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