PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 4, 1996

 Article

Apoptosis in Untreated and Hormone-Treated Prostate Cancer of Various Histological Types

Béla SZENDE1, Thomas LÜBBEN2, Imre ROMICS2, László VASS3

11st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary
2Department of Urology, National Institute for Rheumatology and Physiotherapy, Budapest, Hungary
3Ferenc Flór Hospital, Kistarcsa, Hungary

 

A total of 102 (66 untreated and 36 hormone-treated) prostate cancers were examined histologically in order to determine their histological grade and the percentage of apoptotic tumor cells. The less differentiated the tumors were, the higher the spontaneous apoptotic activity was. Hormone therapy increased the apoptotic index in the prostate cancers. The increase was of greater significance in grade I than in grade II and grade III tumors. The therapeutic consequences of these findings and the possibility of different oncogene-expressions in various histological types of prostate cancer are discussed. Pathology & Oncology Research, Vol 2, Nr 4, 239-241, 1996

Key words: apoptosis; prostate cancer; hormone therapy


Received: Oct 13, 1996; accepted: Dec 12, 1996
Correspondence: Béla SZENDE, 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllõi út 26. Budapest H-1085, Hungary; Tel: 36-1-2661638/4433, Fax: 36-1-1171074; E-mail: bszende@korb1.sote.hu

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