PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 4, 1996

 Report

Granular Cell Variant of Atypical Fibroxanthoma

Zsolt OROSZ1, János KELEMEN1, Zoltán SZENTIRMAY2

1Department of Human and Experimental Tumorpathology, National Institute of Oncology, Budapest, Hungary
2Department of Molecular Pathology, National Institute of Oncology, Budapest, Hungary

 

We report a case of atypical fibroxanthoma of the ear in which the dominant part of the tumor has granular cell appearance. Areas identical to conventional atypical fibroxanthoma were present only at the lateral infiltrating borders. Histologically the granular cells resembled those of the classical granular cell tumors but exhibited significant pleomorphism and a high mitotic rate. Immunostains for vimentin, CD68 and NK1/C3 were positive but for S-100, HMB-45, myogenic and epithelial markers were negative. The predominance of the granular cells in an atypical fibroxanthoma supports the concept that a small subset of tumors with granular cell phenotype are of nonneural origin. Pathology & Oncology Research, Vol 2, Nr 4, 244-247, 1996

Key words: fibrohistiocytic tumors; granular cells; atypical fibroxanthoma


Received: Dec 5, 1996; accepted: Dec 20, 1996
Correspondence: Zsolt OROSZ, Department of Human and Experimental Tumorpathology, National Institute of Oncology, Ráth György u. 7-9. Budapest H-1122, Hungary

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