PATHOLOGY & ONCOLOGY RESEARCHVol. 2 No. 4, 1996

 Report

Contradictory Concepts in the Etiology and Regression of Kaposi's Sarcoma

The Ferenc Györkey Memorial Lecture

Joseph G SINKOVICS1

1Cancer Institute, St. Joseph's Hospital, Tampa, USA
2Departments of Medicine & Medical Microbiology, University of South Florida College of Medicine, Tampa, USA

 

The Introduction is an overview of 3 decades of works performed by Professor Ferenc Györkey? (in many cases in collaboration with the author) and aimed at the elucidation of viral participation in the etiology of arteriosclerosis, SLE, hairy cell leukemia, HD, AIDS and KS. Controversial issues surrounding the etiology, treatment and regression of KS are discussed in terms of paracrine and autocrine loops of growth factors; protooncogene-oncogene activations, immunosuppression and retro- and/or herpesviral etiology. In regressing KS lesions the roles played by Fas, Bcl-2, Bax, TNFß; apoptotic-antiapoptotic events; and antiangiogenesis agents especially that of Hu-r-IFNa are elaborated on. Pathology & Oncology Research, Vol 2, Nr 4, 249-267, 1996

Key words: Growth factor cascade; human herpesvirus 8; apoptosis; protooncogenes-oncogenes; retro-lentiviruses


Received: Nov 20, 1996; accepted: Dec 15, 1996
Correspondence: Joseph G SINKOVICS, Cancer Institute, St. Joseph's Hospital, 3001 W. MLK Jr. Blvd. Tampa 33607, USA; Tel: 813-8704251, Fax: 813-8747218

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