PATHOLOGY & ONCOLOGY RESEARCHVol. 10 No. 3, 2004

 Seminar

Chondrosarcoma Cell Differentiation

Experimental data and possible molecular mechanisms

Joseph G SINKOVICS

Cancer Institute, St. Joseph's Hospital, Departments of Medicine and Medical Microbiology-Immunology, The University of South Florida College of Medicine, Tampa, USA

 

A mixed population of lymphocytes from a healthy donor co-existed with an established culture of allogeneic chondrosarcoma cells, during which time the tumor cells changed from malignantly transformed to benign fibroblast-like morphology; from multilayered to a monolayered growth pattern; lost their potency to grow in colonies in soft agar; and showed signs of senescence. A discussion of possible molecular mechanisms for this event is offered. If there are as yet undiscovered lymphokines that can induce reversal of the malignant geno/phenotype, the cognate gene(s) should be cloned for genetic engineering and for the mass production of the corresponding molecular mediators for clinical trials. Pathology & Oncology Research, Vol 10, Nr 3, 174-187, 2004

Key words: chondrocytes; chondrosarcoma cells; immune T cell; NK cell; cytotoxic lymphocytes; tumor cell differentiation; telomerase


Received: Apr 5, 2004; accepted: Aug 10, 2004
Correspondence: Joseph G SINKOVICS, Cancer Institute, St. Joseph's Hospital, Departments of Medicine and Medical Microbiology-Immunology, The University of South Florida College of Medicine, Dr Martin Luther King Jr Blvd Tampa 3001 W, USA; Tel: (813) 870-4225, Fax: (813) 870-4825

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