PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 4, 1999

 Report

A Solitary Cutaneous Tumor with Distinct Areas of Verruca and Seborrheic Keratosis-like Lesion

Andreas Ch LAZARIS, Helen PARASKEVAKOU, Panayiotis S DAVARIS

Department of Anatomic Pathology, The Medical School of the Athens National University, Athens, Greece

 

A single, exophytic, cutaneous tumor on the thigh of a 52-year-old man was examined by light microscopy, in situ hybridization and immunohistochemistry. It demonstrated distinct areas of verruca and of seborrheic keratosis-like morphology simultaneously. Focally, architectural abnormalities were noted in some deeper parts of the tumor, but there was no morphological evidence of malignancy. The patient has remained disease-free for two and a half years after surgery. Biotinylated full genomicDNA probes of HPV confirmed the presence of types 6/11 exclusively in the verrucous portion of the neoplasm. In the verrucous component p53 protein was overexpressed and, additionally, increased Ki-67 immunopositive signals were detected, being localized below the HPV-DNA-expressing spinous cells. Pathology & Oncology Research, Vol 5, Nr 4, 320-323, 1999

Key words: HPV; seborrheic keratosis; skin; in situ hybridization


Received: Mar 30, 1999; accepted: Oct 25, 1999
Correspondence: Andreas Ch LAZARIS, Department of Anatomic Pathology, The Medical School of the Athens National University, 75 Mikras Asias Str., Goudi Athens GR-115 27, Greece; Tel: 003-01-8843619, Fax: 003-01-7781487; E-mail: alazaris@cc.uoa.gr

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