PATHOLOGY & ONCOLOGY RESEARCHVol. 10 No. 4, 2004

 Article

Incapacitating Lower Limb Pain Syndrome in Cord Blood Stem Cell Transplant Recipients with Calcineurin Inhibitor

Aiko KIDA1, Kazuteru OHASHI1, Takeshi KOBAYASHII1, Miwa SAKAI1, Takuya YAMASHITA1, Hideki AKIYAMA1, Shuji KISHIDA2, Hisashi SAKAMAKI1

1Hematology Division, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
2Neurology Division, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

 

Calcineurin-inhibitor induced pain syndrome (CIPS) is a newly described entity with a characteristic feature of sudden onset of severe lower limb pain, and high levels of cyclosporine or tacrolimus may be involved in the pathogenesis. This syndrome is rarely seen in recipients of hematopoietic stem cell transplantation (HSCT) compared with other organ transplant recipients, however, heightened awareness of this complication after HSCT may be needed for hematologists, as misdiagnosis can result in catastrophic consequences. We report herein two cases of lower limb pain syndrome, with some clinical features resembling CIPS, occurring during the early phase of cord blood stem cell transplantation for hematological malignancy. Pathology & Oncology Research, Vol 10, Nr 4, 204-206, 2004

Key words: calcineurin inhibitor; lower limb pain; pruritus; cord blood stem cell transplantation


Received: Sep 20, 2004; accepted: Oct 27, 2004
Correspondence: Kazuteru OHASHI, Hematology Division, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku Tokyo 113-8677, Japan; Tel: +81-3-3823-2101, Fax: +81-3-3824-1552; E-mail: k.ohashi@cick.jp

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