PATHOLOGY & ONCOLOGY RESEARCHVol. 11 No. 1, 2005

 Article

Expression of p53, Ki-67 and Bcl-2 in Parathyroid Adenoma and Residual Normal Tissue

Tuvia HADAR1, Jacob SHVERO1, Eitan YANIV1, Eduard RAM2, Itzhak SHVILI1, Rumelia KOREN3

1Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
2Department of Surgery A, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
3Department of Pathology, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

 

The aim of this study was to investigate the expression of Ki-67, bcl-2 and p53 in parathyroid adenomas and their residual rim of normal parathyroid tissue. Specimens from 26 parathyroid adenomas were studied by immunohistochemical analysis for Ki-67, bcl-2 and p53 expression. Positive findings were noted for p53 in 4 (15%) adenomas and none of the residual rims of normal parathyroid tissue (p = 0.055); for Ki-67 in 15 (56%) adenomas and none of the residual rims of normal parathyroid tissue (p = 0.00002); and for bcl-2 in 19 (73%) adenomas and 8 (31%) residual rims of normal parathyroid tissue (p < 0.01). The high rate of Ki-67 expression may indicate susceptibility of parathyroid adenomas to clonal proliferation. The weak immunoreactive expression of p53, combined with a relatively strong expression of bcl-2, may contribute to the characteristic slow progression of these tumors. Pathology & Oncology Research, Vol 11, Nr 1, 45-49, 2005

Key words: parathyroid adenoma; normal tissue; p53; Ki-67; bcl-2


Received: Oct 26, 2004; accepted: Dec 30, 2004
Correspondence: Rumelia KOREN, Department of Pathology, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv Tel Aviv 69978, Israel, Fax: 972-3-9372349; E-mail: rumelia@isdumail.co.il

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