Familial Cystic Nephroma in Two Siblings with Pleuropulmonary Blastoma

Nebil BAL1, Fazilet KAYASELCUK1, Ay?e POLAT2, Filiz BOLAT1, Zerrin YILMAZ3, Ilhan TUNCER1

1Department of Pathology, Adana Teaching and Medical Research Center, Adana, Turkey
2Department of Pathology, Mersin University Faculty of Medicine, Mersin, Turkey
3Department of Medical Biology and Genetics, Baskent University Faculty of Medicine, Ankara, Turkey


Cystic nephroma (CN) and pleuropulmonary blastoma (PPB) are rare tumors. In the cases presented here, a 13-month-old boy underwent right radical nephrectomy for CN. From the family history we learned that four years ago the patient’s older sister underwent left radical nephrectomy for CN at a different center when she was 4 years old. A lung tumor was detected in the sister one year after nephrectomy. Biopsy from the lung tumor revealed PPB, and the sister died within one year after biopsy. To the knowledge of the authors, these cases represent the second reported familial occurrence of CN and the fourth of CN and PPB. Pathology & Oncology Research, Vol 11, Nr 1, 53-56, 2005

Key words: Cystic nephroma; familial tumors; pleuropulmonary blastoma

Received: Jan 4, 2005; accepted: Feb 5, 2005
Correspondence: Nebil BAL, Department of Pathology, Adana Teaching and Medical Research Center, Adana Hastanesi, Yüre ir Adana 01250, Turkey; Tel: +90 322 327 2727, Fax: +90 322 3271276; E-mail:

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