PATHOLOGY & ONCOLOGY RESEARCHVol. 11 No. 2, 2005

 Review

Genomics of Pancreatic Cancer: Does It Make Any Improvement in Diagnosis, Prognosis and Therapy?

László KOPPER1, Attila ZALATNAI1, József TÍMÁR2

11st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
2Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary

 

Pancreatic cancer (PanC) is an extremely lifethreatening neoplasm due to its late discovery, rapid progression and resistance to chemo- and radiotherapy. In the past years a significant research attention turned to this cancer. Extensive genomic analysis of PanC revealed numerous alterations, however, none of them emerged yet as a key regulator of tumor progression. Our increasing knowledge on the molecular targets in various cancer types started to change their management. Examples of success of the molecular therapies (in CML, GIST, NSCLC) may initiate more activity in pancreatic cancer as well. Pathology & Oncology Research, Vol 11, Nr 2, 69-73, 2005

Key words: pancreatic cancer; genomics


Received: May 4, 2005; accepted: Jun 11, 2005
Correspondence: László KOPPER, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllõi út 26. Budapest H-1085, Hungary; Tel: +36 13170891, Fax: +36 13170891; E-mail: kopper@korb1.sote.hu

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