Proliferative Lesions of Prostate: a Multivariate Approach to Differential Diagnosis

Fernanda de Barros Correia CAVALCANTI1, Venâncio Avancini Ferreira ALVES1, Julio PEREIRA1, Cristina T KANAMURA2, Alda WAKAMATSU2, Luís Balthazar SALDANHA1

1Department of Pathology, Sao Paulo University School of Medicine, Sao Paulo, Brazil
2Division of Pathology, Adolfo Lutz Institute, Sao Paulo Public Health Service, Sao Paulo, Brazil


Prostatic needle biopsies from 142 patients were studied: 61 cases were ''benign”, 19 atypical small acinar proliferation, 31 high-grade prostatic intraepithelial neoplasia, and 31 adenocarcinoma. Using univariate analysis of 46 previously described morphological features, 16 variables were selected, which were followed by multivariate discriminant analysis. Of these parameters, seven (glandular fusion, crystalloids, nucleolomegaly, papillary architecture, visibility of basal cell layer, areas of normal luminal cell nucleus/cytoplasm ratio and areas of high luminal cell nucleus/cytoplasm ratio) remained significant in discriminating the groups. Multivariate analysis selected a small panel of histological features as those most helpful in the differential diagnosis of proliferative lesions in prostate biopsies. Pathology & Oncology Research, Vol 11, Nr 2, 103-107, 2005

Key words: prostatic hyperplasia; prostatic intraepithelial neoplasia; atypical small acinar proliferation; prostate cancer; histological features

Received: Jul 26, 2004; accepted: Jan 3, 2005
Correspondence: Venâncio Avancini Ferreira ALVES, Department of Pathology, Sao Paulo University School of Medicine, Av. Dr. Arnaldo 455 Sao Paulo 01246-802, Brazil; Tel: 0055112882421, Fax: 0055112882421; E-mail:

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