PATHOLOGY & ONCOLOGY RESEARCHVol. 6 No. 1, 2000

 Article

CRP, TNF-alpha, IL-1ra, IL-6, IL-8 and IL-10 in Blood Serum of Colorectal Cancer Patients

Janina KAMINSKA1, M M KOWALSKA1, M P NOWACKI2, M G CHWALINSKI2, A RYSINSKA1, M FUKSIEWICZ1

1Department of Tumor Markers, Maria-Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland
2Department of Colorectal Cancer, Maria-Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland

 

Blood serum cytokines: TNFa a, IL-1ra, IL-6, IL-8, IL-10 as well as CRP were investigated in patients with colorectal cancer, prior treatment and 1, 10 and 42 days after surgery. There was an increase of the levels of CRP, IL-6 and IL-10 in most patients 24 hours after surgery. The levels of IL-1ra were elevated in patients in stage C and in several patients in stage B of the disease and there was a decrease of circulating TNFa ain stage B patients. On day 10 and 42 after surgery, the levels of cytokines followed various patterns. Pathology & Oncology Research, Vol 6, Nr 1, 38-41, 2000

Key words: cancer; colorectal; cytokines; CRP


Received: Aug 30, 1999; accepted: Oct 10, 2000
Correspondence: Janina KAMINSKA, Department of Tumor Markers, Maria-Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Roentgen 5 Warsaw 02-781, Poland; Tel: (+4822) 6447607, Fax: (+4822) 6447607

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