PATHOLOGY & ONCOLOGY RESEARCHVol. 6 No. 1, 2000

 Article

Serum Levels of the Soluble Adhesion Molecules in Patients with Malignant Melanoma

Vildan YASASEVER, Faruk TAS, Derya DURANYILDIZ, Hakan CAMLICA, Sidika KURUL, Nejat DALAY

Oncology Institute, Department of Basic Oncology, Capa-Istanbul, Turkey

 

The incidence of malignant melanoma has been steadily increasing over the past decades. CD 44 is a transmembrane glycoprotein which is implicated in a number of adhesive and migratory events. Downregulation of CD 44 is implicated in the metastatic process. P-Selectin is a member of the selectin family of cell surface molecules. The levels of P-Selectin in biological fluids may be elevated in subjects with a variety of pathological conditions. In malignant melanoma, elevation of the plasma level of soluble intercellular adhesion molecule-1 (sICAM-1) has been associated with a reduction in disease-free survival. This study was performed to investigate the differences in the serum concentrations of the adhesion molecules in patients with malignant melanoma.The study group consisted of 52 patients with malignant melanoma and 20 healthy subjects. No meaningful difference was observed for P-selectin and sICAM 1 levels. A statistically significant decrease was observed in the cancer patients for serum CD 44 levels. Pathology & Oncology Research, Vol 6, Nr 1, 42-45, 2000

Key words: CD 44; adhesion molecules; malignant melanoma


Received: Aug 30, 1999; accepted: Dec 20, 1999
Correspondence: Nejat DALAY, Oncology Institute, Department of Basic Oncology, Capa-Istanbul 34390, Turkey, Fax: +90 212534 80 78; E-mail: ndalay@yahoo.com

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