PATHOLOGY & ONCOLOGY RESEARCHVol. 11 No. 3, 2005

 Report

An Unusual Case of Posttransplant Peritoneal Primary Effusion Lymphoma with T-cell Phenotype in a HIV-negative Female, not Associated with HHV-8

Ioannis VENIZELOS1, Demetrio TAMIOLAKIS2, Maria LAMBROPOULOU3, Sylva NIKOLAIDOU2, Sophia BOLIOTI2, Hlias PAPADOPOULOS3, Nikolas PAPADOPOULOS3

1Department of Pathology, Ippokratio General Hospital of Salonica, Salonica, Greece
2Department of Cytology, General Hospital of Chania, Chania, Greece
3Department of Histology-Embryology, Democritus University of Thrace, Alexandroupolis, Greece

 

Primary effusion lymphoma (PEL) is a recently individualized form of non-Hodgkin’s lymphoma (WHO classification) that mainly develops in HIV infected males, more frequently in homosexuals and advanced stages of the disease (total CD4+ lymphocyte count below 100-200/µL). Occasionally, it appears in other immunodepressive states (such as solid organs transplant period) and even, although very rarely, in immunocompetent patients. From a pathogenetic point of view, PEL has been related to Kaposi’s sarcoma associated herpes virus (also named human herpesvirus 8, HHV-8), an etiological factor of Kaposi’s sarcoma. The relative infrequency of this disease, the absence of wide casuistics allowing a better characterization, and its unfavorable outcome support the need of a deeper knowledge. We present here the clinical-biological findings of a patient, HIVseronegative, who was diagnosed with peritoneal PEL of T-cell origin, and not HHV-8-associated, five years after renal transplantation. Pathology & Oncology Research, Vol 11, Nr 3, 178-181, 2005

Key words: primary effusion lymphoma; non-Hodgkin’s lymphoma; immunohistochemistry


Received: Apr 27, 2005; accepted: Jun 30, 2005
Correspondence: Nikolas PAPADOPOULOS, Department of Histology-Embryology, Democritus University of Thrace, Dragana Alexandroupolis 68100, Greece; Tel: +3025510-30526, Fax: +3025510-30526; E-mail: npapad@med.duth.gr

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