Chromosome 1p36 and 22qter Deletions in Paraffin Block Sections of Intracranial Meningiomas

Zerrin YILMAZ1, Feride Iffet SAHIN1, Basar ATALAY2, Özlem ÖZEN3, Hakan CANER2, Murad BAVBEK2, Beyhan DEMIRHAN3, Nur ALTINÖRS2

1Department of Medical Genetics, Baskent University Faculty of Medicine, Ankara, Turkey
2Department of Neurosurgery, Baskent University Faculty of Medicine, Ankara, Turkey
3Department of Pathology, Baskent University Faculty of Medicine, Ankara, Turkey


Meningiomas are the most frequent benign tumors of the intracranial cavity. The classification and underlying pathogenetic mechanisms have been reported to be investigated by both pathological and genetic methods. In this study, we aimed to detect 1p36 and 22qter deletions by fluorescence in situ hybridization (FISH) in archival materials of 50 intracranial meningioma patients. The clinical material consisted of paraffin-embedded tissue sections from 50 patients who were surgically treated and had histopathologic diagnosis of an intracranial meningioma. We observed 1p36 deletion in 23/50 (46%) and 22qter deletion in 33/50 (66%) patients. In addition, we observed 22qter deletion in 26/36 (72.2%) patients with meningothelial meningioma. This finding implies that 22qter deletion might play an important role in the pathogenesis of meningothelial meningioma. On the other hand, no alterations were documented in the frequency of these chromosomal alterations according to the grade of meningiomas, suggesting that malignant progression of these tumors depends on other, more relevant, genetic changes. Pathology & Oncology Research, Vol 11, Nr 4, 224-228, 2005

Key words: meningioma; 22q; 1p36; fluorescence in situ hybridization; grading

Received: Jun 29, 2005; accepted: Nov 22, 2005
Correspondence: Feride Iffet SAHIN, Department of Medical Genetics, Baskent University Faculty of Medicine, Kubilay Sokak No: 36 06570-Maltepe Ankara , Turkey; Tel: +90 312 2324400/138, Fax: +90 312 2323912; E-mail:

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