PATHOLOGY & ONCOLOGY RESEARCHVol. 11 No. 4, 2005

 Article

Diagnostic Value of Tumor Markers for Differentiating Malignant and Benign Pleural Effusions of Iranian Patients

Sied Mohammad Ali GHAYUMI1, Samrad MEHRABI1, Mehrnossh DOROUDCHI2, Abbas GHADERI3

1Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
3Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran

 

In order to evaluate the diagnostic yield of tumor markers in differentiating malignant and benign pleural effusions, we carried out a prospective study in a group of Iranian people. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA 15-3), neuron-specific enolase (NSE) and cancer antigen 125 (CA 125) were assayed prospectively in patients with pleural effusion (40 malignant and 37 benign). The highest sensitivity was obtained with a combination of CA 15-3 in serum, and CA 15-3 and CEA in pleural fluid (80%), also with combination of CA 15-3 in serum, and CA 15-3, NSE and CEA in pleural fluid (80%). The highest specificity was obtained with combination of CA 15-3 in serum, and CA 15-3 and NSE in pleural fluid (100%), and also with combination of CA 15-3 in serum, and CA15-3, NSE and CEA in pleural fluid (100%). Pathology & Oncology Research, Vol 11, Nr 4, 236-241, 2005

Key words: pleural effusion; tumor markers


Received: Jun 6, 2005; accepted: Oct 21, 2005
Correspondence: Sied Mohammad Ali GHAYUMI, Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz , Iran; Tel: 0098 711 230 3687, Fax: 0098 711 230 4952; E-mail: ghayyoumim@sums.ac.ir

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