Tumor Sinuses - Vascular Channels

Facts and fictions

József TÍMÁR1, Jeannette TÓTH2

1Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
2Department of Ophthalmology, Semmelweis University, Budapest, Hungary


The existence of tumor cell-lined sinuses (vascular channels) in various experimental and human cancer is known for almost a half a century described by a Hungarian pathologist, Béla Kellner. Meanwhile, even the existence as well as the pathomechanism and the possible functional significance of these sinuses are heavily challenged in the recent literature. Ultrastructural studies however provide evidence for the presence of tumor cell-lined sinuses in human melanoma and breast cancer. The generation of such sinuses can be suggested in two ways: by de novoformation, when tumor cells recapitulate an embryonic geno- and phenotype by reexpressing endothelial genes or by a secondary mechanism, where the incorporated microvessels degenerate due to the predominant expression of anti-angiogenic factors. Literature data are available for the potential diagnostic and clinical significance of the tumor sinuses (vascular channels) stimulating further studies on this issue. Pathology & Oncology Research, Vol 6, Nr 2, 83-86, 2000

Key words: tumor sinus; vascular channel; melanoma; breast cancer; pathomechanism

Received: Mar 1, 2000; accepted: Apr 2, 2000
Correspondence: József TÍMÁR, Department of Tumor Progression, National Institute of Oncology, Budapest, Ráth Gy. u. 7-9. Budapest H-1122, Hungary; Tel: +36 1 224 8786, Fax: +36 1 224 8620; E-mail:

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