PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 1, 2006

 Article

Reduced E-cadherin and α-catenin Expressions Have No Prognostic Role in Bladder Carcinoma

Ismail Turker KOKSAL1, Mutlu ATES1, Ahmet DANISMAN1, Cem SEZER2, Akif CIFTCIOGLU2, Gulten KARPUZOGLU2, Metin SEVUK1

1Department of Urology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
2Department of Pathology, Akdeniz University, Faculty of Medicine, Antalya, Turkey

 

In various human cancers, dysfunction of the E-cadherin-catenin complex is associated with a decrease in cellular and tissue differentiation, and with higher invasive and metastatic potentials. The objective of this study was to investigate E-cadherin and α-catenin expression in superficial noninvasive papillary TCC and invasive TCC, and correlate these results with pathological and clinical parameters. We have used immunohistochemistry to localize Ecadherin and α-catenin in 56 formalin-fixed, paraffin-embedded tissue blocks from 41 patients with superficial bladder cancer and 15 with invasive bladder cancer. The 46 male and 10 female patients had a mean age of 67 years, with range of 40 to 82 years. The mean follow-up time was 33.4 (range 5-120) months. Tumor grade 1:2:3 ratios were 5:32:19. In superficial bladder tumor, abnormal expression of E-cadherin and α-catenin was demonstrated in 37 and 71% of the tumors, respectively. In advanced bladder tumor, abnormal expression of E-cadherin and α-catenin was demonstrated in 80 and 100% of the tumors, respectively. Differences in expression of E-cadherin and α-catenin could be discerned between superficial and advanced bladder tumors (p=0.004, p=0.024, respectively). However, the association between E-cadherin and α-catenin expression and tumor grade was not statistically significant (p>0.05). In addition, the expression of E-cadherin and α-catenin did not correlate with tumor number and size (p>0.05). We have demonstrated that abnormal expression of E-cadherin and/or α-catenin occurs in more than 85% of bladder carcinomas and correlates significantly only with advanced stage. Nevertheless, these observations need to be confirmed in larger prospective clinical studies. Pathology & Oncology Research, Vol 12, Nr 1, 13-19, 2006

Key words: E-cadherin; α-catenin; transitional cell carcinoma; urinary bladder


Received: Oct 11, 2005; accepted: Dec 15, 2005
Correspondence: Ismail Turker KOKSAL, Department of Urology, Akdeniz University, Faculty of Medicine, Dumlupinar Bulvari, Campus Antalya 07070, Turkey; Tel: +90 (242) 227 43 43, Fax: +90 (242) 227 44 82; E-mail: tkoksal@akdeniz.edu.tr

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