PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 1, 2006

 Article

The Intratumoral Microvessel Density and Expression of bFGF and nm23-H1 in Colorectal Cancer

Sahande ELAGOZ1, Reyhan EGILMEZ1, Ayhan KOYUNCU2, Ahmet MUSLEHIDDINOGLU1, Sema ARICI1

1Department of Pathology, Cumhuriyet University School of Medicine, Sivas, Turkey
2Department of General Surgery, Cumhuriyet University School of Medicine, Sema, Turkey

 

It has previously been reported that intratumoral microvessel density (IMD), and the expression of bFGF and nm23-H1 are useful prognostic markers in colorectal cancer (CRC). In this study, a total of 100 CRCs were evaluated histopathologically, and IMD, bFGF and nm23-H1 expression were assessed by immunohistochemistry. IMD of patients increased with grade and stage, and this increase was statistically significant (p<0.05). A significantly higher incidence of high bFGF expression scores was also associated with increasing grade and stage (p<0.05). However, there was no significant difference between the grades in nm23-H1 expression (p=0.234). nm23-H1 expression occurred with lower incidence in stages C1, C2 and D than in stages B1 and B2 (p<0.05). Thus, a negative correlation was found between nm23-H1 expression and stage or lymph node metastasis (LNM) (p<0.05). IMD and bFGF expression were positively correlated with grade, stage, LNM, and lymphovascular invasion. Although positive correlation was found between IMD and bFGF, nm23-H1 expression negatively correlated with both of them. As a result, in clinical practice, increased IMD and bFGF expression and decreased nm23-H1 expression may provide valuable information in characterizing the malignant phenotype. Pathology & Oncology Research, Vol 12, Nr 1, 21-27, 2006

Key words: Colorectal cancer; microvascular density; basic fibroblast growth factor; nm23-H1


Received: May 31, 2005; accepted: Nov 20, 2005
Correspondence: Sahande ELAGOZ, Department of Pathology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey; Tel: +346 2191300, Fax: +346 2191284; E-mail: selagoz@cumhuriyet.edu.tr

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