PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 1, 2006

 Article

p53 Codon 72 Polymorphism in Basal Cell Carcinoma of the Skin

Abdulmohammad PEZESHKI1, Fatemeh SARI-ASLANI2, Abbas GHADERI3, Mehrnoosh DOROUDCHI1

1Shiraz Institute for Cancer Research (ICR), Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran

 

Basal cell carcinoma (BCC) is the most prevalent cancer in Iran. A common polymorphism at codon 72 of exon 4 of p53 tumor suppressor gene has been reported to be associated with increased inheritable susceptibility to several cancers. In the present study the frequency of p53 codon 72 polymorphism in 91 patients with BCC of skin, compared to 465 healthy normal individuals, was investigated. In total, there was no significant difference in the p53 genotypes between patients and controls. However, there was an apparent increase in the Arg/Arg genotype among those BCC patients who had a history of occupational sun exposure, compared to non-exposed patients (46.3% vs. 23.1%, P=0.11). A trend of increase in the frequency of Arg allele among sun-exposed patients was also observed (69.4% vs. 53.8%, P=0.07). Comparison of the genotype frequencies between sunexposed patients and normal controls confirmed the accumulation of Arg/Arg genotype in these patients (46.3% vs. 34.8%, P = 0.07). In addition, the frequency of Arg allele was significantly higher in sunexposed patients compared to controls (69.4% vs. 58.2%, P=0.03). Our results suggest that Arg allele at codon 72 of p53 gene might affect the risk of ultraviolet-induced basal cell carcinoma. Pathology & Oncology Research, Vol 12, Nr 1, 29-33, 2006

Key words: basal cell carcinoma; p53; polymorphism; sun exposure


Received: Jul 5, 2005; accepted: Oct 31, 2005
Correspondence: Mehrnoosh DOROUDCHI, Shiraz Institute for Cancer Research (ICR), Shiraz University of Medical Sciences, Shiraz , Iran; Tel: +98-711-2303687, Fax: +98-711-2304952; E-mail: mdoroud@sums.ac.ir

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