PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 1, 2006

 Report

EBV+ Lymphoepithelial Carcinoma of the Parotid Gland in Mexican Mestizo Patients with Chronic Autoimmune Diseases

Milena SAQUI-SALCES, Braulio MARTINEZ-BENITEZ, Armando GAMBOA-DOMINGUEZ

Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, México

 

Lymphoepithelial carcinomas of the salivary gland are rare tumors constantly associated with Epstein-Barr virus (EBV) and mainly identified in Asiatic and Greenlander population. Four cases have been described in Caucasians, only two with EBV infection. We describe two cases of parotid gland lymphoepithelial carcinomas in Mexican mestizo women in which chronic latent EBV infection was documented by immunohistochemistry and in situ hybridization. One patient had primary Sjögren’s syndrome and the other systemic lupus erythematosus of six and three years of evolution, respectively. Epithelial neoplastic cells showed latency pattern II (LMP1+, EBNA-2-, EBER+) with a dense inflammatory infiltrate composed mainly by CD8+ T lymphocytes. Follow-up excluded nasopharyngeal involvement in both patients. This report expands the ethnic groups in which salivary lymphoepithelial carcinomas associated with chronic latent EBV infection have been described, and illustrates for the first time its association with autoimmune diseases in two women living in a region non-endemic for this unusual neoplasm. Pathology & Oncology Research, Vol 12, Nr 1, 41-45, 2006

Key words: lymphoepithelial carcinoma; Epstein-Barr virus; autoimmune disease; salivary glands


Received: Oct 12, 2005; accepted: Dec 10, 2005
Correspondence: Armando GAMBOA-DOMINGUEZ, Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No 15 Tlalpan 14000, México; Tel: 52/5573-1200/2185, Fax: 52/5513-5395; E-mail: agamboad@quetzal.innsz.mx

Click here to get the full-text version in PDF!
ad