PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 1, 2006

 Report

Prenatal Diagnosis of a Giant Congenital Primary Cerebral Hemangiopericytoma

Gábor SOBEL1, Judit HALÁSZ2, Katalin BOGDÁNYI1, István SZABÓ1, Katalin BORKA2, Péter MOLNÁR3, Zsuzsa SCHAFF2, Ferenc PAULIN1, Ferenc BÁNHIDY1

12nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
22nd Department of Pathology, Semmelweis University, Budapest, Hungary
3Department of Pathology, Medical Center, Debrecen, Hungary

 

Congenital primary intracranial hemangiopericytomas are exceptionally rare tumors. We present a case of a fetus, with the prenatal sonogram at 33 weeks of gestation revealing a large cerebral tumor. Because of the enlarged head, a cesarean section was performed. The tumor was confirmed by postnatal ultrasound, magnetic resonance imaging (MRI) and biopsy. Elevated intracranial pressure and hemorrhage led to death on the 11th day. Autopsy revealed a 10x9 cm large inhomogeneous tumor located centrally, mainly in the posterior fossa. Histology showed a hypercellular and hypervascular tumor with extended necrosis and high mitotic rate. The tumor cells were positive for vimentin and CD34 antigens and negative for several neurological markers, desmin and CD31. The diagnosis of a congenital primary cerebral hemangiopericytoma was confirmed. Pathology & Oncology Research, Vol 12, Nr 1, 46-49, 2006

Key words: congenital brain tumors; infantile hemangiopericytoma


Received: Oct 18, 2005; accepted: Nov 20, 2005
Correspondence: Zsuzsa SCHAFF, 2nd Department of Pathology, Semmelweis University, Üllõi út 93. Budapest H-1091, Hungary; Tel: +36-1 2156921, Fax: +36-1 2156921; E-mail: schaff@korb2.sote.hu

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