PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 2, 2006

 Article

HLA Class II Polymorphism: Protective or Risk Factors to Breast Cancer in Tunisia?

Amal BACCAR HARRATH1, Besma YACOUBI LOUESLATI1, Wafa TROUDI1, Slama HMIDA2, Syrine SEDKAOUI1, Amel DRIDI2, Afef JRIDI2, Farhat BEN AYED3, Khaled BEN RHOMDHANE3, Amel BEN AMMAR ELGAAIED1

1Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, ElManar University, Tunis, Tunisia
2Tunisian Center of Blood Transfusion, Tunis, Tunisia
3Salah Azeiz Oncology Institute, Tunis, Tunisia

 

HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLADRB1* 07-DQB1*02 and the incidence of breast cancer in the Tunisian population. Pathology & Oncology Research, Vol 12, Nr 2, 79-81, 2006

Key words: HLA; DRB1; DQB1; breast cancer


Received: Oct 3, 2005; accepted: Mar 18, 2006
Correspondence: Amal BACCAR HARRATH, , ,

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