PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 2, 2006

 Article

Prevalence of Hormone Receptors and HER2/neu in Breast Cancer Cases in Jordan

Maher A SUGHAYER1, Maha M AL-KHAWAJA1, Suleiman MASSARWEH2, Mahmoud AL-MASRI3

1Department of Pathology, King Hussein Cancer Center, Amman, Jordan
2Department of Medical Oncology, Amman, Jordan
3Department of Surgical Oncology, Amman, Jordan

 

The management and prognosis of breast cancer nowadays require the evaluation of Estrogen (ER), Progesterone Receptors (PR) and HER2/neu. Ethnic variation in the expression of these receptors is well documented. The aim of this study is to determine the prevalence of ER, PR and HER2/neu among Jordanian women with breast cancer of ductal and lobular types. A retrospective analysis was performed on 267 cases of breast cancer referred for treatment at King Hussein Cancer Center, Jordan between the period of June 2003 and June 2004. Standard immune stains were used for evaluation of hormone receptors and HER2/neu. In addition, evaluation of HER2/neu was done by FISH in selected cases. Of these 267 cases, 240 (89.9%) were ductal carcinomas of various histological grades, 122 (50.8%) of which were ER-positive, 138 (57.5%) PRpositive and 42 (17.5%) HER2/neu-positive. Twentytwo (8.2%) of all cases were lobular carcinomas, 15 (68%) of which were ER-positive, 20 (90.9%) PRpositive and 3 (13.6%) HER2/neu-positive. Five (1.9%) of the total cases were of mixed lobular and ductal types, 4 (80%) of which were ER-positive, 3 (60%) PR-positive and none were positive for HER2/neu. The prevalence of hormone receptor positivity in breast cancer of Jordanian women is lower than that of the western populations and close to other populations such as the Chinese and the minor ethnic groups of Northern America (African Americans). Pathology & Oncology Research, Vol 12, Nr 2, 83-86, 2006

Key words: breast cancer; hormone receptors; HER2/neu


Received: Jun 10, 2005; accepted: Mar 5, 2006
Correspondence: Maher A SUGHAYER, Department of Pathology, King Hussein Cancer Center, Queen Rania AlAbdullah Str. Amman 11941, Jordan; Tel: +962-777491216, Fax: +962-6-5342567

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