Immunohistochemical Expression of EGFR and p-EGFR in Oral Squamous Cell Carcinomas

Yukihiro HIRAISHI, Takeshi WADA, Ken NAKATANI, Kenji NEGORO, Shigeyuki FUJITA

Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Wakayama, Japan


Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family, which is expressed or highly expressed in a variety of solid tumors, including oral cancers. High EGFR expression has been correlated with tumor size, metastasis and survival. In recent years, EGFR has been considered a promising target for monoclonal antibody therapy. A total of 52 patients with oral squamous cell carcinoma (OSCC) were selected for EGFR and phosphorylated EGFR (p-EGFR) detection. Immunohistochemical staining was performed to evaluate EGFR and p-EGFR expression. Positive EGFR and p-EGFR staining was present in 92.3% (48/52) and 98.0% (51/52) of all cases, respectively. High EGFR and p-EGFR expression was present in 63.4% (33/52) and 69.2% (36/52) of all cases, respectively. EGFR and p-EGFR expression did not correlate with the clinical factors tumor stage, regional lymph node metastasis, or distant metastasis. However, a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion. As a conclusion, the majority of OSCCs highly express EGFR and p-EGFR, indicating the importance of studying the efficacy of anticancer therapy targeting these signal factors. Pathology & Oncology Research, Vol 12, Nr 2, 87-91, 2006

Key words: EGFR; p-EGFR; oral squamous cell carcinomas

Received: Feb 17, 2006; accepted: May 10, 2006
Correspondence: Yukihiro HIRAISHI, Department of Oral and Maxillofacial Surgery, Wakayama Medical University, 811-1 kimiidera Wakayama 641-8509, Japan; Tel: + 81-73-441-0643, Fax: + 81-73-441-0643; E-mail:

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