PATHOLOGY & ONCOLOGY RESEARCHVol. 12 No. 3, 2006

 Report

Post-menopausal Bleeding: a Rare Presentation of Metastatic Uveal Melanoma

Michael A COUTTS1, Nicola J BORTHWICK2, John L HUNGERFORD3, Ian A CREE4

1Cellular Pathology, Preston Hall Hospital, Maidstone and Tunbridge Wells NHS Trust, Kent, England
2Department of Pathology, Institute of Ophthalmology, University College London, Bath Street, London, England
3Ocular Oncology Service, Moorfields Eye Hospital, City Road, London, England
4Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, England

 

Uveal melanoma differs from cutaneous melanoma in many ways, including its pattern of metastasis, and exhibits latency with clinical evidence of metastasis sometimes appearing many years after primary diagnosis. Most patients develop metastasis within the liver, but some may present with metastasis to other sites. We report a case of uveal melanoma that presented with post-menopausal bleeding due to metastasis. Further investigation revealed widespread metastatic disease and the patient was not fit for chemotherapy. She died two months after presentation: autopsy revealed metastases in many sites, including the uterus, right ovarian fibroma, kidney, mesentery, liver, lung, thyroid, bone marrow and skin. The immediate cause of death was cardiac tamponade due to a malignant effusion secondary to cardiac metastasis. This case illustrates the widespread metastatic potential of uveal melanoma and highlights the potential for unusual presentation of metastatic disease from this eye tumor. Pathology & Oncology Research, Vol 12, Nr 3, 184-187, 2006

Key words: melanoma; eye; uveal; endometrium; post-menopausal bleeding; metastasis


Received: Aug 10, 2006; accepted: Aug 31, 2006
Correspondence: Ian A CREE, Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth PO6 3LY, England; Tel: 02392 286378, Fax: 02392 286379; E-mail: ian.cree@porthosp.nhs.uk

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