Divergences in Diagnosing Nodular Breast Lesions of Noncarcinomatous Nature

Gábor CSERNI1, Zsolt OROSZ2, Janina KULKA3, Zoltán SÁPI4, Endre KÁLMÁN5, Rita BORI1

1Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
2Department of Pathology, National Institute of Oncology, Budapest, Hungary
32nd Department of Pathology, Semmelweis University, Budapest, Hungary
4Department of Pathology, St John's Hospital, Budapest, Hungary
5Institute of Pathology, University of Sciences at Pécs, Pécs, Hungary


Nodular breast lesions of noncarcinomatous origin are often of fibroepithelial origin. They may cause classification problems when they are hypocellular or hypercellular; the latter setting may also raise the differential diagnosis of phyllodes tumors. Thirty equivocal nodular breast lesions were collected and one hematoxylin and eosin slide from each was assessed by six pathologists with special interest in breast pathology. The overall reproducibility of classifying these lesions into categories of fibroadenoma, phyllodes tumor or anything else was moderate (kappa value: 0.48). The lack of a uniform nomenclature was not felt disturbing for hypocellular lesions, but the discordant diagnosis of tumors resembling or representing phyllodes tumors was acknowledged to require intervention, such as more obvious implication of guidelines and quality assurance programs aiming at assessing diagnoses and prognostic parameters. Pathology & Oncology Research, Vol 12, Nr 4, 216-221, 2006

Key words: fibroepithelial breast tumors; nodular lesions; phyllodes tumor; phylloid tumor; fibroadenoma

Received: Jan 23, 2006; accepted: Oct 21, 2006
Correspondence: Gábor CSERNI, Department of Pathology, Bács-Kiskun County Teaching Hospital, Nyíri út 38. Kecskemét H-6000, Hungary; Tel: 36 76 516768, Fax: 36 76 516768; E-mail:

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