Subcutaneous Metastasis of Peritoneal Mesothelioma Diagnosed by Fine-Needle Aspiration

Lina PAPPA1, Melpomeni MACHERA1, Eleni TSANOU1, Constantina DAMALA1, Dimitrios PESCHOS2, Maria BAFA1, Vassiliki MALAMOU-MITSI1

1Department of Pathology-Cytology, Medical School University of Ioannina, Ioannina, Greece
2Department of Forensic Medicine and Toxicology, University of Ioannina, Ioannina, Greece


Mesothelioma is a rare malignant neoplasm of the serosal membranes, which can give distant metastases in various organs in advanced stages of its course. Subcutaneous tissue is an unusual metastatic site. In the literature, only one case of metastatic mesothelioma to the skin of the face has been reported. We present a case of a 60-year-old female with a prior history of peritoneal malignant mesothelioma, who 6 months after the initial diagnosis presented with a subcutaneous nodule in the lateral chest wall. Cytological examination of the material obtained by FNA from the nodule revealed metastatic mesothelioma. Although subcutaneous metastasis of malignant mesothelioma is a rare entity, one must always keep this possibility in mind and proceed to further investigation of such lesions. In these cases, FNA is a simple diagnostic procedure for the identification of metastatic disease in patients with a prior history of malignancy. Pathology & Oncology Research, Vol 12, Nr 4, 247-250, 2006

Key words: mesothelioma; metastatic nodules; FNA; cytology

Received: Feb 20, 2006; accepted: Jun 16, 2006
Correspondence: Vassiliki MALAMOU-MITSI, Department of Pathology-Cytology, Medical School University of Ioannina, Ioannina 45110, Greece; Tel: +302651-0-97767, Fax: +302651-0-97893; E-mail:

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