PATHOLOGY & ONCOLOGY RESEARCHVol. 13 No. 1, 2007

 Article

Prevalence of SLC22A4 1672T and SLC22A5 -207C Combination Defined TC Haplotype in Hungarian Ulcerative Colitis Patients

Lili MAGYARI1, Judit BENE2, Katalin KOMLÓSI1, Gábor TALIÁN1, Bernadett FARAGÓ1, Veronika CSÖNGEI1, Luca JÁROMI1, Enikõ SÁFRÁNY1, Csilla SIPEKY1, Lilla LAKNER3, Márta VARGA4, Beáta GASZTONYI5, Béla MELEGH1

1Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary
2MTA PTE Clinical Genetics Research Group of Hungarian Academy of Sciences, University of Pécs, Pécs, Hungary
3Department of Medicine and Gastroenterology, Markusovszky Hospital, Szombathely, Hungary
43rd Department of Medicine and Gastroenterology, Réthy Pál Hospital, Békéscsaba, Hungary
51st Department of Medicine, School of Medicine, University of Pécs, Pécs, Hungary

 

Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract. The aim of this study was to verify the prevalence rate of the haplotype called TC, determined by combination of two functional alleles of OCTN cation transporter genes (SLC22A4 1672T and SLC22A5 -207C combination variants) in ulcerative colitis patients and unrelated healthy controls. The ''TC haplotype” has recently been suggested to confer risk for UC. A total of 121 unrelated Hungarian subjects with UC and 110 matched controls were genotyped for the two single nucleotide polymorphisms. The genotypes were determined by using PCR/RFLP assay and direct sequencing. The SLC22A4 1672T allele frequency was 46.7% in the patients with UC and 46.4% in the controls, whereas the SLC22A5 -207C allele occurred in 48.8% of the patients and 51.4% of the controls. The prevalence of the TC haplotype was 19% in the patient group and 22.7% in controls. Since there was no accumulation of the TC haplotype in the patient group, our observation suggests that carrying the TC haplotype is not associated with a higher risk for UC in the Hungarian population. Pathology & Oncology Research, Vol 13, Nr 1, 53-56, 2007

Key words: ulcerative colitis; OCTN1; OCTN2; SLC22A4; SLC22A5; TC haplotype


Received: Oct 24, 2006; accepted: Dec 15, 2006
Correspondence: , Department of Medical Genetics and Child Development, University of Pécs, Szigeti út 12 Pécs H-7624, Hungary; Tel: (+36)-72-536-427, Fax: (+36)-72-536-427; E-mail: Bela.Melegh@aok.pte.hu

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