PATHOLOGY & ONCOLOGY RESEARCHVol. 13 No. 2, 2007

 Article

Association between Microvessel Density and Histologic Grade in Renal Cell Carcinomas

Nikolaos KAVANTZAS, Helen PARASKEVAKOU, Sofia TSELENI-BALAFOUTA, Kyriaki ARONI, Pauline ATHANASSIADES, George AGROGIANNIS, Efstratios PATSOURIS

Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

 

Angiogenesis seems to contribute to tumor growth and the development of metastases. There may be an association between the vascular density of individual tumors and their prognosis. In the present survey we studied 53 cases of renal cell carcinoma investigating possible relationship between histologic grade and microvessel density (MVD) measured by an image analysis system. According to our results MVD was significantly associated with the histologic grade, higher grades being accompanied with a higher MVD. Further studies are needed to investigate a possible connection of MVD with the prognostic role of grade in RCCs. Pathology & Oncology Research, Vol 13, Nr 2, 145-148, 2007

Key words: renal carcinoma; microvascular density


Received: Nov 2, 2005; accepted: Mar 25, 2007
Correspondence: George AGROGIANNIS, Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 60 Agias Lavras str. Athens GR-157 73, Greece; E-mail: agrogeorge@panafonet.gr

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