Bcl-2 and MALT1 Genes are not Involved in the Oncogenesis of Uterine Tumors Resembling Ovarian Sex Cord Tumors

Sanda SITIC1, Petra KORAC1, Petra PEHAREC2, Gojko ZOVKO3, Marija Milkovic PERISA1, Slavko GASPAROV1

1Department of Clinical Pathology and Cytology, Clinical Hospital Merkur, Zagreb, Croatia
2Department of Clinical Pathology, Clinical Hospital Centre, Zagreb, Croatia
3University Clinic for Gynecology and Obstetrics, Department of Gynecological Oncology, Clinical Hospital Merkur, Zagreb, Croatia


Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare entities. They were described by Clement and Scully in 1976 who classified them into groups I and II. Group I comprises typical endometrial stromal neoplasms with focal areas resembling ovarian sex cord elements and group II are predominantly or completely composed of ovarian sex cord-like elements. We report a case of UTROSCT type II with cytogenetic analysis. The tumor occurred in a 76-year-old woman who presented with vaginal bleeding. The tumor was lobulated, firm, yellow and histologically composed of sex cord-like elements. Tumor cells expressed vimentin, CD10, CD99 and alpha-actin. Cytogenetic analysis in a previously reported case detected translocation t(4;18)(q21.1;q21.3) in the majority of cells. Bcl-2 and MALT1 genes are located at or near the translocation breakpoints, and the aim of this study was to determine whether these genes were involved in chromosomal translocation or tumorigenesis. We did not find IgH translocation or the most common MALT translocations. Bcl-2 was also not involved in this oncogenesis. Pathology & Oncology Research, Vol 13, Nr 2, 153-156, 2007

Key words: uterus; ovarian sex cord tumors; Bcl-2; MALT1; translocation

Received: Oct 11, 2006; accepted: Mar 20, 2007
Correspondence: Sanda SITIC, Department of Clinical Pathology and Cytology, Clinical Hospital Merkur, Zajceva 19 Zagreb , Croatia; Tel: +38512431410, Fax: +38512343500; E-mail:

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