Metastatic Renal Clear Cell Carcinoma in the Parotid Gland: A Study of Immunohistochemical Profile and Cell Adhesion Molecules (CAMs) Expression in Two Cases

Dimitrios ANDREADIS, Alexandros NOMIKOS, Calypso BARBATIS

Department of Histopathology, Hellenic Red Cross Hospital of Athens, Athens, Greece


Metastasis of renal cell carcinoma (RCC) may involve any organ, including the parotid salivary gland. While the definition of salivary gland neoplasms with clear cell transformation can be concluded by the synchronous presence of areas showing typical morphology, sometimes the definition of a metastatic RCC in the parotid is difficult and the application of immunohistochemistry may support the clinical and radiographic observations in the final diagnosis. The aim of this paper was to describe the heterogeneous immunohistochemical features and, furthermore, to characterize the pattern of expression of cell adhesion molecules (CAMs) E-cadherin, beta4-integrin, desmoglein-2, ICAM-1 and CD44s (HCAM) in two cases of metastatic parotid RCC. Pathology & Oncology Research, Vol 13, Nr 2, 161-165, 2007

Key words: metastatic renal cell carcinoma; parotid gland; cell adhesion molecules; immunohistochemistry

Received: Oct 30, 2006; accepted: Mar 20, 2007
Correspondence: Dimitrios ANDREADIS, Department of Histopathology, Hellenic Red Cross Hospital of Athens, 4 Sarantaporou St Athens 155-61, Greece; Tel: +302108014928, Fax: +302104836883; E-mail:

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