PATHOLOGY & ONCOLOGY RESEARCHVol. 6 No. 3, 2000

 Article

Retrospective Evaluation of 5-fluorouracil-interferon-a aTreatment of Advanced Colorectal Cancer Patients

Csilla ANDRÁS1, Zoltán CSIKI1, István GÁL1, István TAKÁCS2, Lajos ANTAL1, Gyula SZEGEDI1

13 rd Department of Internal Medicine, Medical Faculty, University of Debrecen, Debrecen, Hungary
22 nd Department of Surgery, Medical Faculty, University of Debrecen, Debrecen, Hungary

 

The authors describe the retrospective analysis of treatment by 5-fluorouracil and interferon-a aof 34 patients with advanced colorectal cancer. An average of 4.6 treatment cycles (3–12) was applied. Complete remission was not observed; partial remission was observed in 8 patients; in 13 patients no change occurred and progression was detected in 14 cases. Remission rate was 22.8%, mean response time was 5.2 (3–12) months, mean progress-free survival 5.6 (0–22) months. Mean survival from the start of treatment was 11.9 (1–42) months and from the establishment of the diagnosis 26.1 (3–60) months. Severe life-threatening side-effects did not occur; other side-effects such as fever, nausea, diarrhea, leucopenia, and anemia responded to drugs. Treatment by 5-FU and interferon, in accordance with other authors’ findings, improved survival and well-being of patients but no breakthrough has been achieved. Pathology & Oncology Research, Vol 6, Nr 3, 175-178, 2000

Key words: advanced colorectal cancer; interferon; 5-FU; survival


Received: Jan 11, 2000; accepted: Sep 10, 2000
Correspondence: Csilla ANDRÁS, 3 rd Department of Internal Medicine, Medical Faculty, University of Debrecen, Móricz Zs. Krt. 22. Debrecen H-4004, Hungary; Tel: 36 52 414-969, Fax: 36 52 414-969

Click here to get the full-text version in PDF!
ad