PATHOLOGY & ONCOLOGY RESEARCHVol. 13 No. 4, 2007

 Article

Prognostic Significance of Loss of c-Fos Protein in Gastric Carcinoma

Seon Pil JIN1, Ji Hun KIM3, Min A KIM1, Han-Kwang YANG2, Hee Eun LEE4, Hye Seung LEE4, Woo Ho KIM1

1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
2Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
3Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
4Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea

 

c-fos was first identified as a viral oncoprotein, and has been studied in terms of its oncogenic function in tumorigenesis. Many experimental and clinical data indicated that c-fos expression plays a role in the progression of several types of carcinomas. However, some recent studies challenge this view as they indicate that c-fos has tumor suppressor activity. In the present study, we assessed c-fos protein expression in 625 consecutive gastric cancers immunohistochemically, and analyzed its relationship with clinicopathologic factors and survival. We found that a loss of c-fos expression is correlated with a more advanced stage, lymph node metastasis, lymphatic invasion and shorter survival, indicating that c-fos expression in gastric cancer cells is lost during progression and that this loss is associated with a poor prognosis. The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos. Pathology & Oncology Research, Vol 13, Nr 4, 284-289, 2007

Key words: stomach neoplasms; immunohistochemistry; survival analysis; proto-oncogene protein c-fos; tumor suppressor protein; tissue array analysis


Received: Apr 13, 2007; accepted: Oct 12, 2007
Correspondence: Woo Ho KIM, Department of Pathology, Seoul National University College of Medicine, 28 Yeongeon-dong Seoul 110-799, Korea; Tel: 82-2-740-8269, Fax: 82-2-765-5600; E-mail: woohokim@snu.ac.kr

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