PATHOLOGY & ONCOLOGY RESEARCHVol. 13 No. 4, 2007

 Article

Increase of Hypophyseal Hormone Levels in Male Head and Neck Cancer Patients

Éva REMENÁR1, Irén SZÁMEL2, Barna BUDAI3, Borbála VINCZE4, István GAUDI5, Sarolta GUNDY6, Miklós KÁSLER1

1Department of Head and Neck, Laser and Reconstructive Plastic Surgery, National Institute of Oncology, Budapest, Hungary
2Department of Medical Oncology ''B'', National Institute of Oncology, Budapest, Hungary
3Clinical and Experimental Laboratory, National Institute of Oncology, Budapest, Hungary
4Department of Biochemistry, National Institute of Oncology, Budapest, Hungary
5Department of Onkocytogenetics, National Institute of Oncology, Budapest, Hungary
6National Cancer Registry, National Institute of Oncology, Budapest, Hungary

 

Head and neck squamous cell carcinoma (HNSCC) develops in at least 80% of cases in men with a history of smoking and heavy alcohol consumption, still it is only diagnosed in a small proportion of alcoholics. Endocrine milieu is an important factor in carcinogenesis and prognosis of several cancer types. The aim of our study was to investigate sex steroid and hypophyseal hormone status of male HNSCC patients in comparison to healthy volunteers and to patients with alcoholic liver disease, to determine possible hormonal alterations characteristic of cancer. Liver function (GGT level), and serum levels of gonadotropic hormones (FSH, LH, prolactin), sex steroids (estradiol, progesterone, testosterone) and sex hormone-binding globulin (SHBG) were compared in 130 male HNSCC patients, 54 patients with alcoholic liver disease but no known cancer, and 56 healthy controls. We found abnormal values of liver function in both HNSCC patients and alcoholics compared to healthy controls, suggesting the presence of alcoholic liver disease in the former group as well. On the other hand, a significant elevation in the level of DHEA, FSH and LH was observed in cancer patients exclusively. As a conclusion, abnormal alterations in sex steroid hormone levels can frequently be found in HNSCC patients, which may be caused in part by the alcoholic liver damage accompanying the disease. The significant increase in FSH and LH serum levels, observed only in the cancer patients, indicates that these hormones may play a role in the development and/or progression of HNSCC. Pathology & Oncology Research, Vol 13, Nr 4, 341-344, 2007

Key words: head and neck cancer; sex steroids; hypophysis hormones; alcoholic liver disease


Received: Sep 5, 2007; accepted: Sep 20, 2007
Correspondence: Éva REMENÁR, Department of Head and Neck, Laser and Reconstructive Plastic Surgery, National Institute of Oncology, , Ráth Gy. u. 7-9. Budapest H-1122, Hungary; Tel: 36-1-2248600, Fax: 36-1-2248662; E-mail: reva@oncol.hu

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