Histopathological Variation of Primary Mucosa-associated Lymphoid Tissue Lymphoma of the Oral Cavity

Masaru KOJIMA1, Naoya NAKAMURA2, Kazuhiko SHIMIZU3, Masahumi NISHIKAWA4, Morio MATSUMOTO5, Keiko HIGUCHI6, Nobuo YAMANE7, Norihumi TSUKAMOTO8, Yoshio TAMAKI6, Hiroshi INAGAKI9

1Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan
2Department of Pathology, Tokai University School of Medicine, Isehara, Japan
3Department of Pathology and Clinical Laboratories, Ashikaga Red Cross Hospital, Ashikaga, Japan
4Department of Pathology and Clinical Laboratories, National Tochigi Hospital, Utsunomiya, Japan
5Department of Hematology, National Nishigunma Hospital, Shibukawa, Japan
6Department of Radiology, Gunma Cancer Center Hospital, Ohta, Japan
7Department of Oral Surgery, Ashikaga Red Cross Hospital, Ashikaga, Japan
8Department of Medicine and Clinical Science, Gunma University, Gunma, Japan
9Department of Pathology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan


Primary mucosa-associated lymphoid tissue (MALT) type lymphoma arising in the oral cavity is rare. We examined histopathologic, immunohistological and genotypic findings of seven cases of intraoral MALT lymphoma using formalin-fixed paraffin-embedded tissues. Histologically, two variants have been delineated. (i) In four cases of minor salivary gland type, the lymphoid follicles were surrounded by centrocyte-like (CCL) cells with occasional follicular colonization. The CCL cells invaded the residual salivary gland duct resulting in a lymphoepithelial lesion. CCL cells frequently showed plasmacytic differentiation. (ii) In three cases of follicular growth type, the lesion was characterized by follicular growth pattern resulting from prominent follicular colonization. CCL cells showed minimal plasma cell differentiation. There was no residual epithelial component detected even by cytokeratin immunostaining. There were no Epstein-Barr virus-encoded small RNA-positive cells detected by in situ hybridization. API2-MALT1 fusion transcript does not appear to be associated with either histological variant of primary intraoral MALT lymphoma. Pathology & Oncology Research, Vol 13, Nr 4, 345-349, 2007

Key words: mucosa-associated lymphoid tissue lymphoma; oral cavity; follicular colonization; immunohistochemistry

Received: Jan 22, 2007; accepted: Oct 25, 2007
Correspondence: Masaru KOJIMA, Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, 617-1, Takabayashinishi-cho Ohta 373-8550, Japan; Tel: +81-276-38-0771, Fax: +81-276-38-8386; E-mail:

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